| Summary: | 碩士 === 輔仁大學 === 食品營養學系 === 93 === The prevalence of osteoporosis in Taiwanese male and female elderly were 48.8 % and 52.9 %, respectively. The prevalence of osteopenia in Taiwanese male and female elderly were 45.2 % and 41.5 %, respectively. The purposes of the current study are to assess the efficiency of calcium and vitamin D supplementation on bone health of elderly using biomarkers of various processes in bone remodeling in coupled with bone mineral density. Twenty-three elderly residences of Yi-Yuan Institute averagely aged 81.3 ± 6.4 year were recruited, and their average daily calcium intake was determined by a 3-day food weighing method. Starting from September of 2003, the elderly subjects were provided with daily supplements of 600 mg of calcium and 120 IU vitamin D for one year. Bone mineral density was determined at the beginning and the end of the study. Serum levels of biomarkers bone metabolism such as osteocalcin, bone-specific alkaline phosphatase, type I C-terminal propeptide, and pyridinoline were measured at the beginning and the end of 6th and 12th months of the study. The total calcium intake and vitamin D supplementation of the study were 1277 ± 374 mg and 108 ± 13 IU. Compliance of subjects assessed by monthly tablet counting was 89.8 ± 10.7 %. The BMD of men were significantly higher than that of women. Prior to supplementation, mean annual BMD change was -0.004 ± 0.001 gm/cm2; mean annual BMD changes one year of supplementation was 0.017 ± 0.011 gm/cm2. The L4 BMD in men increased significantly after 12-month supplement compared to baseline. One year of calcium and vitamin D supplementation maintained BMD. All subjects in baseline had normal BAP, higher OC, lower CICP and slightly higher Pyr compared to reference young adults. Serum BAP significantly decreased after calcium and vitamin D supplementation. OC were significantly higher at twelfth month compared with the sixth month. Serum CICP in male elderly significantly decreased and Pyr tended to increase during study. Bone turnover index significantly increased suggesting a trend of higher bone turnover rate; b-quotient tended to reduce indicating reduced bone formation activity during the study. In conclusion, long term calcium and vitamin D supplementation for elderly maintained their bone mineral density.
|
|---|
