Physiological effects of postexercise carbohydrate supplementation on the evaluation of gene expression in human skeletal muscle
博士 === 輔仁大學 === 食品營養學系 === 93 === The purpose of this study was to determine the physiological effects of postexercise carbohydrate supplementation on the evaluation of gene expression in human skeletal muscle. There were two studies in this theme including the oligonucleotide microarray analysis an...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2005
|
| Online Access: | http://ndltd.ncl.edu.tw/handle/09594691072343671165 |
| Summary: | 博士 === 輔仁大學 === 食品營養學系 === 93 === The purpose of this study was to determine the physiological effects of postexercise carbohydrate supplementation on the evaluation of gene expression in human skeletal muscle. There were two studies in this theme including the oligonucleotide microarray analysis and the evaluation of glucose uptake-associated gene expression of human skeletal muscle. The first study was to compare the effect of ingesting carbohydrates with different glycemic indexs (GIs) during postexercise recovery on metabolism related gene expression in human skeletal muscle. The results of the first study showed that 57 genes were up regulated and 41 genes were down regulated in the high GI trial when compared to the fast trial. The low GI trial showed that 26 genes were up-regulated and 51genes were down-regulated compared to the fast trial.
The previous studies found that the exercise-induced elevation in GLUT4 (glucose transport subtype4, GLUT4) mRNA of rat muscle can be rapidly down-regulated when glucose is given immediately following exercise. The purpose of the second study was to determine the effect of postexercise carbohydrate supplementation on blood biomarkers and skeletal muscle glucose uptake-associated gene expression. The results of the second study suggested that carbohydrate supplementation down regulated GLUT4 and hexokinase II gene expression in human skeletal muscle after strenuous exercise while accompanied by elevated blood glucose and insulin concentrations. Our findings suggest that carbohydrate supplementation may influence blood biomarkers and muscle skeletal metabolism related gene expression during postexercise recovery.
|
|---|