Validity of High Sensitivity C-Reactive Protein and Intimal Medial Thickness of Carotid Artery in predicting patients with significant Coronary Artery Disease

• Main Authors: Chun-Hua, 柯君樺
• Other Authors: 吳得進
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/84106641926903563631

碩士 === 中山醫學大學 === 醫學研究所 === 93 === Background : The incidence of atherosclerosis is increased in Taiwan 。 Large prospective trials have shown high sensitivity C-reactive protein ( hsCRP ) to be a strong predictor of future cardiovascular events and prognosis of the patients。Epidemiologic and clinical studies have shown leucocytosis to be an independent predictor of future cardiovascular events。 Measurement of carotid artery intimal medial thickness ( IMT ) and ankle brachial index ( ABI ) are widely used as non invasive modalities for evaluating peripheral arterial occlusive disease。 But the relationship of these with the diagnosis of coronary artery disease ( CAD ) are not well determined。 In the present study , we determine the relationship between significant coronary artery stenosis in stable coronary artery disease and each of hsCRP , white blood cell counts , carotid IMT and ABI measured before coronary angiography。 Methods : This prospective study enrolled the consecutive patients admitted to our hospital from 1st November 2004 to 30th April 2005 , who was clinically suspected coronary artery disease 。 31 patients without significant CAD and 30 patients with significant CAD were included。 All patients are received blood examination including hsCRP , white blood cell counts , lipid profile , fasting blood sugar, and non invasive investigation such as carotid IMT and ABI measurements。All data are analysed with SPSS 10 version。 Compare between two groups normally distributed continuous variables are used independent student “t” test。 Regression analysis was done between carotid IMT and hsCRP with other variables。 Result : The patients characteristics and parameter between two groups such as lipid profile , fasting blood sugar , body mass index , age , waist circumference , ankle brachial index and white blood cell counts did not show any statistically significant。 Only the carotid IMT and hsCRP show statistically significant ( P-value =0.025 and 0.046 respectively ) 。 With linear regression analysis carotid IMT also shows relationship with age ( P- value=0.02 )。 Conclusion : In patient with suspected coronary artery disease before coronary angiography , the measurement of intimal medial thickness of carotid artery and hsCRP can increase the positive diagnostic rate in significant coronary artery stenosis。 Carotid IMT which is also has relationship with age。