| Summary: | 碩士 === 中山醫學大學 === 營養學研究所 === 93 === Peroxisome proliferator-activated receptor gamma（PPARγ）is a nuclear receptor that regulates adipocyte differentiation and insulin sensitivity. Recent research suggests that Pro12Ala variant in PPARγ is associated with diabetes and obesity. The purpose of this study was to investigate whether prevalence of PPARγ polymorphism and assessment the effects on anthropometric measurement and biochemical. Subjects were identified by type 2 diabetic to have take medicine. Two hundred seventy eight patients successfully completed the study. The man with the mean age of 57.1±11.3 y and the women was 59.7±12.7 y. The Patients were assigned to 1 of 4 groups, with genotype, BMI, HbA1c and TG. The 4 group that basic data and anthropometric measurement was no significant. Result shows that prevalence of Pro/Ala and Ala/Ala was 11% in central Taiwan. There were no significant between genotype groups with respect to BMI. The blood pressure was no significant, but the correlation between diastolic blood pressure with homozygous carriers or heterozygous carriers in women subjects. The heterozygous carriers had lower level of diastolic blood pressure compared with wide type carriers（78.3±8.2 mmHg vs 84.3±14.3 mmHg）. In men, the heterozygous carriers had lower level of total cholesterol compared with wide type carriers（169.4±40.6 mg/dL vs 202.5±36.6 mg/dL，P＜0.05）, and the same with low density cholesterol（105.4±34.0 mg/dL vs 124.3±30.4 mg/dL，P＜0.05）. Further, the triglyceride concentration in heterozygous carriers were lower than wide type carriers（120.0±50.5 mg/dL vs. 150.3±75.6 mg/dL，p =0.06）. In women, the homozygous carriers had higher level of fasting blood sugar compared with the heterozygous carriers（193.0±32.5 mg/dL vs 142.7±27.5 mg/dL，p =0.06）.Our result indicates in central Taiwan in man that PPARγ polymorphism was static significant with respect to total cholesterol and low density cholesterol in the heterozygous carriers, and in Women, the homozygous carriers effect of blood sugar.
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