Study of Sensitivity to Purine Metabolism in Man

• Main Authors: Chin-Hsiung Lee, 李俊雄
• Other Authors: Feng-Sheng Wang
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/63409422535304573812

碩士 === 國立中正大學 === 化學工程研究所 === 93 === Mathematical modeling of purine metabolism in man was shown with regard to Michaelis-Menten (MM) model which was difficult to study on analysis of sensitivity. Therefore, we transferred MM model into GMA model with power-law approximation, Methematica software tools and simulated its dynamic behavior in response to different operating points. From the simulating result of rate constant analysis, we could find the concentration change of ARNA, APRT, GPRT, HPRT, GRPT, and ASLI enzymes would brought about the abnormalities in purine metabolism.. Alternatively, we would focus on the above specific enzymes to study their relative sensitivities with PLAS software tool. In the end, we used GMA model to make a simulating computation by changing the enzyme activities of ASLI in purine metabolic pathway, and compared the simulated result with clinical data, Furthermore, we made a discussion and analysis between the results of the drug therapy on gout patients.