Comparative genome annotation for pathogenic entericbacteria phage analysis between enterohemorrhagic Escherichia coli and other bacteria

• Main Authors: Yu-Wei TSAY, 蔡郁偉
• Other Authors: Ru-Sheng Liu
• Format: Others
• Language: zh-TW
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/33675776228209603945

碩士 === 元智大學 === 資訊工程學系 === 92 === In decades, the varieties of organisms were sequenced and annotated form laboratory accordingly. The bacterium Escherichia coli is one of the most comprehensive analyzed free-living organisms recently. The sequence、metabolic pathway and regulatory mechanism of these bacterium are well understanding to comparison with other bacterium. However, the mere sequenced of E. coli was not enough to understand the pathogenic mechanism precisely, nothing but it’s physical property or patient’s pathological diagnosis to make a compendium determination. We do not know the exact pathogenic mechanism as well as which protein or genes are related presently. An aspect of compare to other similar entericbacteria, most of the papers are discussing these sequenced bacteria and diversity of E. coli, the comparison between harmless E. coli (MG1655) and the extraintestinal pathogenic E. coli strain. Nowadays, research does not present a remarkable conclusion via computational methods. We offer a comparative query tool based on some assumptions for disease potential E. coli between each entericbacteria. By the way of our computation result and statistics with alternative variety of comparison, we enumerate some highly possible pathogenic proteins and region for the results as our reference material.