| Summary: | 碩士 === 大同大學 === 材料工程學系(所) === 92 === Porous biodegradable polymers are widely used in tissue engineering since they can provide a temporary support for cell growth and guide tissue regeneration. Poly(DL-lactide-co-glycolide) (PLGA) and PET are polyester where PLGA is popularly used in bone tissue and other biomedical applications due to its good biocompatibility and controllable biodegradability. Chondroitin-6-sulfate (CS) is the bulk of the matrix that builds vertebral discs, ligaments, cartilage and other connective tissues. Chondroitin sulfate is highly effective in recovery from injury. It can speed up healing time, reduce pain, and provide cushioning to sore, traumatized areas. In this study, plasma treatment and subsequent immobilization of Chondroitin-6-Sulfate on porous poly (DL-lactide-co-glycolide) (PLGA) scaffolds was conducted to improve the wettability, cell-, and tissue-compatibility of the scaffolds. The surface of scaffold was modified through plasma polymerization, surface graft polymerization, and their combination. After surface modification, the wettability of PLGA substrates were characterized by water adsorption ratio, the water adsorption ratio of the Ar plasma treated PLGA scaffolds increased from 201 % to 308 %. However, the water adsorption ratio of hexamethyldisilazane (HMDSZ) plasma deposited scaffolds was decreased to 177.3 %. From SEM and FTIR results, they can demonstrate the Chondroitin-6- Sulfate was immobilized on PLGA scaffolds. Cell adhesion and growth on Chondroitin-6- Sulfate was immobilized on PLGA scaffolds were more pronounced than the original one.
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