Effect of Plasma Cleaning and Plasma Polymerization on Titanium Surfaces

• Main Authors: Cheng Shiung CHEN, 陳正雄
• Other Authors: Che-Tong LIN
• Format: Others
• Language: en_US
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/76535944523121848123

碩士 === 臺北醫學大學 === 口腔復健醫學研究所 === 92 === The surface of implantable biomaterials is in direct contact with the host tissue and plays a critical role in determining biocompatibility. In order to improve implant integration, it is desirable to control interfacial reactions such that nonspecific adsorption of proteins is minimized and tissue-healing phenomena can be controlled. The purpose of this study was to develop a new method to functionalize titanium surfaces by plasma treatment. The covalent immobilization of bioactive organic molecules and the in vitro bioactivity were evaluated by x-ray diffraction (XRD), atomic force spectroscopy (AFM), x-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and MTT assay. Argon plasma removes all adsorbed contaminates and impurities. Plasma-cleaned titanium surfaces showed better bioactive performances than did untreated titanium surfaces. Our results reveal that plasma-cleaned titanium surfaces provide a clean and reproducible starting condition for further plasma treatments to form well-controlled surface layers. Allylamine was ionized by the plasma treatment process, and dangling bonds acted as a medium to link albumin. Cells had spread well, and good attachment was attained on the albumin/allylamine/TiO2/Ti surface. It was revealed that attachment and growth of cells are influenced by the surface properties. The plasma treatment process plays an important role in facilitating tissue healing. This process not only provides a clean titanium surface, but also produces surface amination on plasma-treated titanium surfaces. Surface cleaning by ion bombardment and surface modification by chemical polymerization of plasma treatments are believed to remove contamination on titanium surfaces and hence promote tissue healing.