| Summary: | 碩士 === 臺中健康暨管理學院 === 生物資訊研究所 === 92 === In the past several years, the analysis of alternative splicing and its application to identify the origins of disease has been gaining momentum. Therefore, we developed a value added transcriptome database (Avatar). We mapped EST (expressed sequence tag) and mRNA sequences onto whole human genome sequence. We identified alternative splicing relationships among genes through the analysis of large-scale ESTs.
Our approach to detect alternative splicing is based on whole genome alignment of EST. We used MUGUP[2] to align the entire ESTs set and mRNA to the whole genome
We provided alternative splicing information for six organisms: Homo sapiens, Mus musculus, Rattus norvegicus, Caenorhabditis elegans, Drosophila melanogaster and Arabidopsis thaliana.
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