The effect of Tien Wang Pu Hsin Dan on learning and memory ability in senescence accelerated mice

• Main Authors: Hung-Sheng Ping, 洪昇平
• Other Authors: K.F Huang
• Format: Others
• Language: zh-TW
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/scwby9

碩士 === 靜宜大學 === 應用化學研究所 === 92 === Abstract The purpose of the study was to examine the effects of different concentrations of Tien-Wang-Pu-Hsin-Dan on learning and memory abilities in different age mice. Two and six month old male and female senescence accelerated mice (SAMP8) were divided into five groups. Body weights, food intake, open field activity test, single-trial passive avoidance, and active shuttle avoidance test grading score and were performed, and variation of brain histopathology after sacrificed. The result showed,in learning and memory ability , both female and male in single-trial passive avoidance test and active shuttle avoidance test ,had a better improvement than control group.In the grading score of senescence, both female and male between 2month and 6month mice showed significant differences. The vacuoles and lipofuscin of brain in 6month were better than 2month mice, we conclude that the supplement of Tien-Wang-Pu-Hsin-Dan could improve the abilities of learning and memory and reducing the brain pathological varies, and decrease grading score.