| Summary: | 碩士 === 國立臺灣大學 === 預防醫學研究所 === 92 === Background: Prevalence rates of betel nut chewing and metabolic syndrome (MS) are both high in Taiwan. As genetic factors and environmental factors play important roles in the development of MS, however, the impact of betel quids via inheritance on MS is poorly understood in human being study. The aim of this study was to elucidate whether paternal exposure to betel quids can significantly affect the risk for MS.
Materials and methods: Attendants of a population-based screening program with retrievable parentage relationship were included for this analysis. MS cases were defined according to the modified NCEP ATP III criteria. A total of 5092 pairs of parent-progeny relationship amounting to 11583 subjects with information concerning betel quid chewing, relevant risk factors and MS, were analyzed with Cox proportional hazards regression model.
Results: Offspring with paternal exposure of betel quids were significantly younger in diagnosed age of MS (P < 0.001) with an OR of 2.14 (95% CI:1.25-3.66, P < 0.01), adjusted for individual betel-chewing and other risk factors. After controlling for exercise and intake of vegetable, the effect of paternal exposure on the risk for MS in progeny in the absence of parental MS and without personal chewing history, was still significant (OR=2.53; 95% CI: 1.03-6.24, P=0.04). Besides, testing for trends showed significant dose-response effect according to quantity (P<0.0001), duration (P<0.0001), and intensity (P<0.0001) of betel quid chewing.
Conclusion: The present study corroborates the impact of betel quids on the risk of MS in offspring, which may have a significant implication for the prevention of MS.
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