| Summary: | 碩士 === 國立臺灣大學 === 預防醫學研究所 === 92 === Background: The interrelationships of individual components of metabolic syndrome are intricate and hard to disentangle.
Objectives: The aim of this study was therefore to develop the pathway of MS underlying its components.
Methods: There were total of 456 volunteer participants aged 30 years or older attending a community-based integrated screening in Long-Chi, a remote township of southern Taiwan. A cross-sectional study nested within the screening program was conducted to ascertain metabolic syndrome and to measure indicators of body composition, anthropometric indicators. A structural equation model was adopted to test a series of the proposed pathways to identify the most appropriate ones.
Results
(1) The overall prevalence rate of MS was 31.8% with 41.4% and 19.6% in females and males, respectively.
(2) Indictors for body composition in predicting MS was not superior to those using anthropometric measures such as BMI.
(3) Nine variables were reduced to four components, including “obesity”, “blood lipids”, “blood pressure”, and “insulin resistance”.
(4) There are two major pathways leading to MS. One starts from obesity, which, in turn, increases the risk of developing insulin resistance and also dyslipidemia, two major factors responsible for the risk of MS. The other pathway is through the elevation of blood pressure. It is very interesting to find there was a weak direct effect of obesity on MS. The impact of obesity on blood pressure is also not substantial.
Conclusions: Obesity and body composition are the precursor of MS and insulin resistance or dysplipidemia are two transient states in association with MS. Elevation of blood pressure is another independent pathway to MS.
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