| Summary: | 碩士 === 國立臺灣大學 === 醫學工程學研究所 === 92 === Abstract
Hydrogels are capable of containing large amounts of water and resemble nature living tissue so it can be used in drug delivery for low molecular hydrophobic drugs, hydrophilic drugs, peptides, proteins and genes, and can be used as scaffold in tissue engineering. Due to its biocompatibility and biodegradablility, hydrogels could be easily applied in in vivo experiments.
This research is to synthesize PEG-PLGA-PEG triblock copolymer with the polyethylene glycol and poly(lactide-co-glycolide). This polymers is gel in body temperature and solution in room temperature. It can be used as an implantable drug delivery system which no any surgical operation is needed after drug depleted. The polymers can also be completely metabolized.
These polymers are called temperature-sensitive hydrogels. They are formed by the phase transformation of micelles, the same mechanism as that of pluronics and tetronics. Different temperature makes the solubility change due to the methyl and ethyl functional organic group.
PEG-PLGA-PEG triblock copolymer were synthesized by bulk reaction. The characteristics of polymers were validated by H-NMR. Sol-gel phase diagrams were established by the tube reverse method. Vancomycin in vitro release was conducted in 37℃.Comparing the drug delivery curve verse with the different temperature at 32℃ and 40℃, we proposed a gelation mechanism of these copolymer gels.
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