| Summary: | 碩士 === 國立臺灣大學 === 動物學研究研究所 === 92 === The adhesion of hemocytes plays an important role in the innate immunity of abalones. According to the results from this study, several conclusions were drawn about the role of PKA (protein kinase A) in the adhesion of abalone hemocytes. First, upon cell adhesion, the amount of cAMP decreased in hemocytes. Second, elevation of cAMP levels inhibited cell adhesion. Third, cell adhesion was enhanced by the PKA inhibitor KT5720. Fourth, PKA activity decreased upon adhesion was in a time-dependent manner. Therefore, these results strongly suggested that the adhesion of abalone hemocyte is regulated by PKA and the subsequent signal transduction pathway. However, another cAMP-mediated protein Epac was not involved in the regulation of the adhesion of hemocytes. Besides, since RGD peptides affected the cell adhesion suggested that the adhesion of abalone hemocytes was mediated by the interactions between integrins and fibronection.
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