Ciannamaldehyde and its derivatives inhibit LPS and TPA-mediated transformation in rat glioma C6 cells
碩士 === 國立屏東科技大學 === 生物科技研究所 === 92 === Glia cell which play a pivotal role in immunological defense, readily become activated upon neuronal injury or inflammatory stimulation and release immune modulators such as potentially damaging nitric oxide (NO) , thereby further contributing to transformation...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2004
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| Online Access: | http://ndltd.ncl.edu.tw/handle/46349003483349585593 |
| Summary: | 碩士 === 國立屏東科技大學 === 生物科技研究所 === 92 === Glia cell which play a pivotal role in immunological defense, readily become activated upon neuronal injury or inflammatory stimulation and release immune modulators such as potentially damaging nitric oxide (NO) , thereby further contributing to transformation of glioma.Progression is the final stage of carcinogenesis, and malignant transformation of carcinoma in situ to invasive carcinoma. Cinnamomum cassia has been traditionally used for treating inflammatory disease in both eastern and western countries. Cinnamaldehyde and cinnamyl acetate is the main component of cinnamon bark oil. Therefore, in the experiments of Glioma C6 cell cultures stimulated by lipopolysaccharide (LPS) or 12-ο-tetradecanoylphorbol 13-acetate (TPA). Results showed cinnamaldehyde and cinnamonyl acetate inhibited LPS- and TPA-induced malignant ransformation and NO production in glioma C6 cell. We use real-time PCR to confirm that matrix metalloproteinase-9 enzyme is inhibited expressed in glioma C6 cell.
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