Microfluidic Simulation on the Solid Model of Viruses Detection Chip for the Phalaenopsis Orchid

• Main Authors: Zhi-Ziung Chen, 陳志宗
• Other Authors: Chyung Ay
• Format: Others
• Language: zh-TW
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/21727080940707627390

碩士 === 國立嘉義大學 === 生物機電工程學系碩士班 === 92 === To the traditional virus examination, not only it need long time to do and the operating process tedious but also the product is expensive cost. Therefore, the chip examination system must be developed to substitute the traditional virus examination. In microelectromechanical system (MEMS), it is important to reduce the time west and increase the product developing speed with CAD. When each production chip does some inspection course, the target sample can be able to examination step by step. This study combined the previous developed the Y micro-mixer, the PCR chip, the CE chip which was designed individually by the bottom up and integrate on chip through CoventorWare sofware. Since these three layers used all different analysis module, if the simulation processed at the same time, it need to set two parameter, such as phase operating time and voltage switch function. The phase boundary condition is : Phase 1 : inlet_0 ( Y micro-mixer of the sample input tank ) = 0 v, v_2 ( CE chip of the sample waste liquid tank ) = 220 v, and keep 17.2 seconds, the sample will flow from inlet_0 through intermediate layer PCR chip until v_1 ( CE chip of the sample tank ). Then phase was changed : Phase 2 : v_1 = v_3 ( CE chip of the buffer tank ) = v_4 ( CE chip of the analysis waste liquid tank ) = 0 v, v_2 = 18 v and keep for 0.3 seconds, to eliminate the diffusing phenomena of the CE chip when the sample flowed from v_1 through the cross intersection. Finally Phase 3 was changed : v_3 = 0 v, v_1 = v_2 = 110 v, v_4 = 220 v, when micro sample injection to separate in the pipeline go through the cross intersection place spend 18.1 seconds. It means this design faster than the traditional virus detection.