The studies of E.coli adhesion on polyurethane surfaces with quaternized pyridine moieties in perfusion system

• Main Authors: Li-Cheng Ju, 朱立晟
• Other Authors: Jui-Che Lin
• Format: Others
• Language: zh-TW
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/a26v66

碩士 === 國立成功大學 === 化學工程學系碩博士班 === 92 === 　　Three families of non-release quaternized polyurethane were synthesized by different molar ratio of MDI, PTMO and N, N-bis(2-hydroxyethyl)isonicotinamide (BIN). BIN was used as the chain extender in a series of polyurethane block copolymer. The structure of pyridine on BIN could be quaternized by 1-iodooctane and formed cationic polyurethanes. The structure of cationic polyurethanes was proven by the characterization results of nuclear magnetic resonance (NMR), element analysis (EA) and fourier transform infrared spectroscopy (FTIR). Surface hydrophilicity in water and water absorption ratio were both increased with the quaternization ratio because of incorporation of ionic functionality. The antibacterial capability of cationic polyurethanes was assessed by 24 hours continuous in vitro E. coli perfusion test. The polyurethane with quaternized pyridine group had much more bacterial adhered than electro neutral polyurethane and PE. This should result from the electrostatic interaction between the positive charge along the quaternized pyridine groups and the negative charge associated with bacterial cell membrane. This study shows that the quaternized polyurethane exerts a strong adhesive force on E. coli, even quaternized group possess biocide ability.