The application of asymmetric reformatsky-type reaction in preparing of chiral B-hydroxyamide for the intermediate of new triazole antifungal agents
碩士 === 國立中興大學 === 化學系 === 92 === The asymmetric Reformatsky reaction is a versatile and straight forward approach to obtaining chiral alcohols ( -hydroxy esters), a motif found in biologically active compounds and synthetic intermediates. Although a variety of asymmetric Reformatsky reac...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2004
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| Online Access: | http://ndltd.ncl.edu.tw/handle/47580184868957857448 |
| Summary: | 碩士 === 國立中興大學 === 化學系 === 92 === The asymmetric Reformatsky reaction is a versatile and straight forward approach to obtaining chiral alcohols ( -hydroxy esters), a motif found in biologically active compounds and synthetic intermediates. Although a variety of asymmetric Reformatsky reactions have been developed. In our study the compound 3 with -hydroxycarboxylic acid was reported as an important intermediate of triazole antifungal agent. We found the Reformatsky reaction with acetophenone (Ketone) was carried out under the metal-halogen exchange reaction of the α-Bromo oxazolidinones with diethyl zinc and catalyst loading of Ni(acac)2. And we obtained that the best diastereoselectivity up to 97%, which provide a practical method to synthesize the new triazole antifungal agents.
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