| Summary: | 碩士 === 高雄醫學大學 === 職業安全衛生研究所碩士班 === 92 === Objective:
To study the temporal change of urinary 1-hydroxypyrene (1-OHP) in coke–oven workers after exposed to polycyclic aromatic hydrocarbons (PAHs).
Method:
From October, 2003 to March, 2004, 18 top-side oven workers and 41 side-oven workers from one coke oven plant of a large steel company were studied. Personal ambient PAHs exposures were measured in the 1st and 6th working days, whereas individual spot urine specimens were collected in the first day before work and after work, the third day after work, and the sixth day before and after work as well as the seventh and eighth day’s morning, and the first day before work in the following working shift. GC/MS and HPLC-FLD were used to measure ambient PAHs and urinary 1-OHP levels.
Results:
Top-side oven workers were exposed to significantly higher ambient PAHs concentrations than sideoven workers (mean ± SE＝8357.44 ± 4261.46 ng/m3 v.s. 1196.81 ± 265.56 ng/m3, p < 0.001). 1-OHP concentrations in the first day before work were significant higher in top-side oven workers than in sideoven workers (mean ± SE＝236.23 ± 70.00 v.s. 35.17 ± 9.93μg / g creatinine, p < 0.001). Among the top-side oven workers, the trend of 1-OHP increased sharply from the first day before work and became a plateau in the sixth day before (443.67 ± 125.47 μg / g creatinine)and after work (424.62 ± 91.43μg / g creatinine). And it declined dramatically in the 8th day morning(201.53 ± 49.41μg / g creatinine). In contrast, in sideoven workers, 1-OHP concentrations increased slowly and reached to the top in the third day after work(70.54 ± 13.09μg / g creatinine) and the sixth day before work (61.93 ± 10.52μg / g creatinine).
Conclusion:
Top-side oven workers were exposed to significantly higher ambient PAHs concentrations than sideoven workers. The excretion of 1-OHP was also significantly higher in top-side oven workers than sideoven workers. In addition, the patterns of the temporal change of 1-OHP concentrations in top-side oven workers and sideoven workers were different.
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