Electrophilic Induced Cyclization of Methyl 2-(6-substitued 3-hexen-1,5-diynyl)benzoate :Synthesis ofIsocoumarins
碩士 === 高雄醫學大學 === 藥學研究所碩士在職專班 === 92 === Treatment of methyl 2-(6-substitued 3(Z)-hexen-1,5-diynyl) benzoates with four equivalent of iodine in CH2Cl2 at room temperature gave 4-iodo-3-((1E,3E)-4-substituted-3,4-diiodo-1,3-butadienyl)isocou- marins in 47- 68 % yields. When the amount of iodine was r...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2004
|
| Online Access: | http://ndltd.ncl.edu.tw/handle/84913048776455415353 |
| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所碩士在職專班 === 92 === Treatment of methyl 2-(6-substitued 3(Z)-hexen-1,5-diynyl) benzoates with four equivalent of iodine in CH2Cl2 at room temperature gave 4-iodo-3-((1E,3E)-4-substituted-3,4-diiodo-1,3-butadienyl)isocou- marins in 47- 68 % yields. When the amount of iodine was reduced to one equivalent, the reaction gave 4-iodo-3-((E)-4-substituted-1-buten-3-ynyl) isocoumarins in 57- 67 % yields. Other iodinating agents are also introduced in this reaction, similar results were observed when ICl and NIS were employed in this reaction.
|
|---|