| Summary: | 碩士 === 高雄醫學大學 === 牙醫學研究所碩士班 === 92 === Many studies have reported the association between periodontal disease and preterm low birth weight (PLBW) infants. Several pathways have proposed to link the periodontal disease to the occurrences of PLBW infants. However, the evidences are still limited to clarify the mechanisms. Our study collected the plasma and the gingival crevicular fluid (GCF) samples at early and late trimesters (1st and 3rd trimester or 2nd and 3rd trimesters) of pregnant women and examined the relations among results of clinical periodontal examinations, the levels of PGE2, IL-1β and TNF-α in the plasma and the levels in the GCF of the 33 pregnant women. We found that the periodontal clinical parameters of these pregnant women were not associated with the concentration and the total amount of PGE2(Mean±SD: 101.0±73.8 ng/ml, 89.7±26.5 pg/30s), IL-1β(29.1±29.9 ng/ml, 36.9±29.3 pg/30s) and TNF-α(158.4±131.4 pg/ml, 0.116±0.102 pg/30s) in 30-seconds GCF samples, and the concentration of PGE2(2.18±1.74 ng/ml) and TNF-α(1.07±0.556 ng/ml) in plasma (p > 0.05). There was no significant relation between the concentration and the total amount of PGE2, IL-1β and TNF-α in 30-second GCF samples and the concentration of plasma- PGE2 (p > 0.05). The concentration of GCF-PGE2, GCF-IL-1β(r = 0.333, p = 0.0385) and GCF-TNF-α(r = 0.483, p = 0.0038) were not associated with plasma-TNF-α (p > 0.05), but the total amount of PGE2(r = 0.424, p = 0.0052), IL-1β and TNF-α in 30-second GCF sample were significantly positively associated with the concentration of plasma-TNF-α (p < 0.05). Our study found that the levels of GCF-PGE2, GCF-IL-1β and GCF-TNF-α were related to the concentration of blood-TNF-α. Further studies are needed to clarify the casual association.
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