Preparation and Release Studies of Controlled-Release Pellets Containing Enteric Polymers

• Main Authors: Chang-Sha Liao, 羅昌霞
• Other Authors: none
• Format: Others
• Language: zh-TW
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/85932923134510202055

碩士 === 嘉南藥理科技大學 === 生物科技系暨研究所 === 92 === This study was aimed to evaluate the effect of formulation as well preparation methods on controlled-release pellets. Ketoprofen (a less water soluble model drug) pellet formulations based on HPC-L or EC as core binders were prepared and evaluated. Moreover, the preparation methods of core pellets using Glatt Rotar Granulators and CF-Granulator were also compared. Then core pellets were subsequently film-coated with EC as controlled release polymer, and the released rates were adjusted by using enteric polymers Eudragit-L or Shellac . The effects of film thickness on dissolution rates were assessed. The surface of pellets was examined by scanning electron microscopy (SEM), whereas the stability of pellets were evaluated by the accelerated test as well as dissolution method. The pharmacokinetic studies using healthy human subjects indicate that the pellets indeed demonstrate controlled-release characteristics in vivo.