The Preformulation Study of Chinese Herbal Cosmeceutics

• Main Authors: Yu Yi Chang, 張有邑
• Other Authors: Gan lin Chen
• Format: Others
• Language: zh-TW
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/32230059580550051078

碩士 === 中國醫藥大學 === 藥物化學研究所 === 92 === Seventeen Chinese herbs had been evaluated in vitro in this study. The extracts of Rhodiola crenulata (Hk. f. et Thoms.) H. Ohba. and Terminalia catappa L. showed higher activities of SOD-like and total antioxidant. The analytical method of HPLC chromatographic fingerprint of Rhodiola crenulata H. Ohba. was established and validated. It could be used as the quality control method in the development of these Chinese herbs. Rhodiola crenulata H. Ohba. and Terminalia catappa L. 5% aqueous extract fluid showed no toxicity and no skin and eye irritation response. The evaluation protocols followed OECD Guidelines for Testing of Chemical. This study focused on Rhodiola crenulata H. Ohba. and Terminalia catappa L. which prepared theirs cream dosage form. The stability studies of the cream were performed under 25 and 35℃ for 90 days. The physico- chemical stability of the cream and salidroside were both satisfied. This study showed that Rhodiola crenulata H. Ohba. and Terminalia catappa L. cream had the potential to be used as the whitening, antiwrinkle, and anti- aging agent in cosmetics.