| Summary: | 碩士 === 臺北醫學大學 === 保健營養學系 === 91 === The purpose of this study was to assess the correlation serum leptin concentration with effectiveness of weight loss. The study was divided into two groups, one was weight loss group and another was control group. In the weight loss group, we were provided with 1200 Kcal/day (CHO: 55 %, FAT: 20 %, PRO: 25 %) for 8 weeks. After three months, we followed body composition and biochemical measurements changes. In the control group, subjects (n = 18, male = 2, female = 16) aged 25 ± 0.8 yrs, body mass index was 20.2 ± 0.3 kg/m2, body fat mass percentage was 24.7 ± 1.3 %. In the weight loss group, subjects (n = 18, male = 4, female = 14) aged 39 ± 1.7 yrs, body mass index was 28.2 ± 3.3 kg/m2, body fat mass percentage was 33.1 ± 1.5 %. The weight loss group which age, weight, BMI, fat free mass, muscle mass, body fat mass percentage, waist-hip ratio, blood sugar, total cholesterol, triacylglyceride, LDL-C and TC/HDL-C were significantly higher than control group (p < 0.05). After 4 and 8 weeks weight loss program, weight, fat mass, muscle mass, BMI, total body water, protein weight, basal metabolic rate, body fat percentage, serum leptin and insulin concentration significantly decreased (p < 0.05). But after 8 weeks weight loss program, waist-hip ratio significantly decreased (p < 0.05). After 3 months follow-up, weight, fat mass, BMI, waist-hip ratio, serum leptin and TSH concentration increased significantly (p < 0.05). The 4 and 8 weeks weight changes significantly positive correlated with baseline leptin concentration and baseline leptin/BMI, but the 3 months follow-up weight changes no significantly correlated with baseline leptin concentration and baseline leptin/BMI. Therefore, during weight loss program, subjects who lose more weight have higher baseline leptin concentration and baseline leptin concentration predicted subsequently weight loss. But baseline leptin concentration failed to predicted weight regain.
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