Preparation and Release Properties of Alginate Microcapsules Containing Vitamin E by Emulsification/Internal Gelation Method

• Main Authors: Ai-Ming Change, 張艾民
• Other Authors: Shann-Tay Lin
• Format: Others
• Language: zh-TW
• Published: 2003
• Online Access: http://ndltd.ncl.edu.tw/handle/40582305776255092846

碩士 === 靜宜大學 === 應用化學研究所 === 91 === Abstract The objective of this study is to explore the effects of the concentration of alginate on the particle size, the drug encapsulation efficiency, the swelling ratio, the gelling yield , and the morphology for microcapsules of alginate and alginate-chitosan.The alginate and alginate-chitosan microcapsules were made by the method of emulsufication/ internal gelation.The properties of microcapsules were measured by varying the polymer concentrations,the reaction temperatures,the stirrer speeds,and the pH values of the solutions.The alginate-chitosan crosslinkage be able to observe by FTIR.The stability of microcapsules is evaluated by Zeta potential in media.Surface morphologies of microcapsules were viewed with a Scanning Electron Microscope. The results show that alginate aqueous solution is a pseudoplastic fluid.1.5﹪alginate solution show the smallest particle size,and the largest drug encapsulation efficiency and largest negative value of Zeta potential of microcapsules as compared with 0.5﹪,1.0﹪,and 2.0﹪of alginate solutions.The microcapsules of alginate-chitosan has a smaller swelling ratio than that of Ca-alginate.We observed the surface character of microcapsules of crosslinkage with SEM,and found the release rates are low down with the fine surface of microcapsules,therefore alginate-chitosan microcapsules can be used for the propose of delaying drug release.