Measurement system for electrophysiological signals - from basic biomedical recording to clinical application

• Main Authors: TSAI YAO CHIH, 蔡曜至
• Other Authors: FU SHAN JAW
• Format: Others
• Language: zh-TW
• Published: 2003
• Online Access: http://ndltd.ncl.edu.tw/handle/88295440369572137881

碩士 === 國立臺灣大學 === 醫學工程學研究所 === 91 === Measurement of physiological signals plays an important role in medical or clinical studies. To meet specific requirements of acquisition of various physiological signals we need to develop adequate monitoring and recording systems for electrophysiological and pain researches in our laboratory. The designed systems are aimed for the recording of multi-channel evoked potentials and for quantitative evaluation of clinical pain. For electrophysiological studies, glass microelectrodes were used to record cerebral evoked potentials, caused by electrical or mechanical stimuli. Then, current-source-density (CSD) analyses were performed to find out the responsive centers. The results show that the somatotopic organization in SI area is clear and the representation of the rat’s tail in this area is very small. The CSD mappings obtained from mechanical stimuli are similar to those of electric stimuli. The effects of anesthetic level on the variation of the evoked responses were also analyzed. This necessitates the use of multi-channel recording systems for saving experimental time, and hence, the reproducibility of the recordings. A total of 16 channels were implemented in this system, which consists of amplifiers and filers. A blood pressure recorder was implemented for physiological monitoring of the rat. Since there is no objective and precise method for pain evaluation in clinic, the other part of this thesis is for this purpose. Surface electromyography and contraction force of a patient’s hand are to be used for quantification of pain. Therefore, circuits for their measurements were developed and tested. Further clinical trials will be carried on by utilizing this system.