Design of adhesive matrix for transdermal delivery of Desferal

• Main Authors: Hsin-Yu Lu, 呂欣育
• Other Authors: Tai-Horng Young
• Format: Others
• Language: zh-TW
• Published: 2003
• Online Access: http://ndltd.ncl.edu.tw/handle/32365083535278562407

碩士 === 國立臺灣大學 === 醫學工程學研究所 === 91 === The ultimate goal of this study is to help thalassemia patients, who chronically require blood transfusions to keep alive. However, such long-term transfusions can easily lead to a build-up of trivalent iron and produce an iron overload condition. To treat iron overload, the patients usually receive intravenous or subcutaneous deferoxamine mesylate (DFO) regularly. But, because of the pain the patients may resist taking drug, so the effects of treatment are not very good. Consequently, we hope to be able to change the method of delivering DFO─we want to see if we can replace the injection method with transdermal drug delivery. The immediate goal of the study, therefore, is to assess the feasibility of designing and fabricating a DFO patch using an adhesive dispersion-type transdermal drug delivery system. It is hoped that it can let the drug pass through the skin at a fixed rate of speed and reach the circulation system, from where it can spread its therapeutic effect throughout the body. In this research, we choose the commercial pressure sensitive adhesives to be the drug reservoirs and observe the release profile of DFO in the adhesives in order to develop and design transdermal patchs. But because drug matrices can only contain a certain amount loading drug, the area of the designed patch is too big. Adding diethylene glycol and tetraethylene glycol to be penetration enhancers, the result is not as good as we expected. But adding Tween 80, it will enhance DFO penetrating through porcine skin in 10 days. We guess DFO is penetrating through porcine skin via sweat glands and hair follicles, a hydrophilic way. And we can find the presence of DFO in the rabbit serum. But the mechanism of the transdermal drug delivery system is needed further research and development.