| Summary: | 碩士 === 國立臺灣大學 === 醫學工程學研究所 === 91 === Evoked responses are widely applied in the study of somatosensory. There is, however, no current-source-density (CSD) analysis obtained from natural form stimulations. Hence, it is not easy to know the distribution of thalamic responses evoked by touch or pain. In this research, auxiliary devices for electrophysiology were designed. A homemade mechanical stimulator that can delivery quantitative mechanical stimulations was used to cause touch sensation in the middle portion of the rat’s tail. The evoked responses were compared with those obtained by electrical stimulation in the same receptive field. The results show that the responsive area is very small. Complete mapping of the tail is located within the range: 3.4-3.7 mm (AP), 3.4-4.2 mm (ML), and 5.2-6.5 mm (VD). Systematic recordings were used to get 2D CSD both on cornary and sagittal planes. The source and sink centers on these planes suggest that the electrical stimulation can not be used to replace the “touch stimulation,” especially in the view point of the thalamus. Nevertheless, data obtained in this study provided a blueprint for further single unit recording.
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