| Summary: | 碩士 === 國立東華大學 === 生物技術研究所 === 91 === At present, there are some common methods to quantify gas determination, such as Gas-Liquid chromatography, Mass spectrometry, and so on. However, the requirements of highly-pure analyzed samples, computer-statistics of mass spectrum figures, expensive instruments and time-consuming analysis all make these methods difficult. We have developed a sensitive, rapid and handy PZ sensor as gas sensor. The definition of biosensor is a sensing tool that combines molecular recognition component of biomaterials with physical transducers to detect the chemicals or the specific interaction in vivo or in vitro.
This study has applied the combinatorial chemistry technology in the field of pharmaceutical research to synthesize pentapeptide sequence library by positional scanning method. The principle is defined as a fixed position of amino acid sequence in every single synthesis; others remain random position that combines molecular recognition component of biomaterials with QCM transducers to screen the target gases for finding a stable, recognized and sensitive peptide sequence. In the cases of ammonia and acetic acid, the sensitivities were raised two to three times, and the analysis was quite stable. This investigation provides a new method to recognize materials for gas sensor. It can be well applied in the fields of medical detection, environmental pollution, biochemical sensing, food industry, etc.
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