| Summary: | 博士 === 國立成功大學 === 電機工程學系碩博士班 === 91 === In this thesis, we propose a new method for analyzing pulsation frequency, which is sensitive to the change in sympathetic and parasympathetic functions.
First, we investigate the relationship between the respiration and blood pulse. The clinical experiments have shown that a slow and regular respiration has a great effect upon the HRV. Such phenomenon is called respiratory sinus arrhythmia (RSA). We find that the fluctuations of harmonics of arterial pulse are also consistent with the fluctuation of HRV. This means that the whole cardiovascular system (CVS) makes a quick adaptation during respiration, and the harmonic proportions of arterial pulse are modified during different breath rates.
In the second part of our study, the pulse pressure data is obtained under control condition and in parasympathetic blocked by atropine. Compared with the spectral method of heart rate variability (HRV), which is wide-spreading in laboratory studies and clinical diagnosis nowadays, the method of pulsation spectrum provides a new and direct view to assess parasympathetic control. As can be seen from the results, the high frequency of pulsation harmonics are reduced by the parasympathetic blocked, and on the contrary, low frequency component increased. By the analysis of linear regression, the pulsation spectrum method indicates more correlations with atropine doses. We anticipate that the non-invasive assessment of short-term autonomic function will come to be performed more reliably and conveniently by using this method.
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