Studies on the Synthesis and Biological Activities of Substituted Indoloquinolines

• Main Authors: Hsien-Ming Hung, 洪憲明
• Other Authors: Cherng-Chyi Tzeng
• Format: Others
• Language: zh-TW
• Published: 2003
• Online Access: http://ndltd.ncl.edu.tw/handle/ut7fpz

碩士 === 高雄醫學大學 === 藥學研究所碩士在職專班 === 91 === Abstract: Fused nitrogen containing heteroaromatic tetracyclo compounds, such as angular indolo[3,2-c]quinolines and linear indolo[2,3-b]quinolines are known as DNA intercalating agent with anticancer activity. Certain substituted indoloquinolines, 6-diamine substituted indolo[3,2-c]quinolines, 11-anilinoindolo[2,3-b]quinolines, and 11-methoxyindolo[2,3-b]quinolines have been synthesized and evaluated in vitro against a 3-cell line panel consisting of MCF7 (Breast), NCI-H460 (Lung), and SF-268 (CNS).