Association of Positive Cervical Smears of Aboriginal Women of Nantou County and Betel Quid Chewing, Cigarette Smoking and Alcohol Intake

• Main Authors: Pai-Chih Peng, 彭百志
• Other Authors: Tien-Yu Shieh
• Format: Others
• Language: zh-TW
• Published: 2003
• Online Access: http://ndltd.ncl.edu.tw/handle/ehnkty

碩士 === 高雄醫學大學 === 口腔衛生科學研究所碩士在職專班 === 91 === Abstract Previous reports indicated that the diseases resulted from the chewing of betel quids mainly located at the oral cavity area were documented by many inevstigatiors. In recent years, the focus has widened more systemic diseases and diseases of other organs. Some investigators have found that the chewing of betel quids suppresses the immune system.. The purpose of this research is to investigate whether betel quids chewing, cigarette smoking, and alcohol intake will also cause pathological changes of the uterine cervix. The study targets the women of two mountainous villages of Nantou County, Hsingi Village and Jenai Village, who have had Pap smears done. Up to the end of 2001 there were 4,654 women who have had Pap smears done. 104 of them were determined to be positive cases with the diagnosis of CIN1 and above. They were categorized as the case research group. After inspection of their tissue section slides, 32 women were found to be positive cases, with 13 having dysplasia, 13 with carcinoma in situ (CIS) and 6 with invasive carcinoma. As for the rest of the negative cases, 104 of them were selected as the comparative group to compare with the ages and residential places of the positive cases. A matching ratio of 1:1 was used, and a questionnaire survey was done. There were 208 valid questionnaires returned. Based on the data, statistical analysis and logarithmic regression analysis were made by using univariate analysis and SAS software. The results showed that the proportion for the positive Pap smear cases of the women of mountainous villages of Nantou County was 2.23%, which was 2 ~ 3 times higher than the incidence in Kaohsiung City (0.72%) and other Taiwan areas(1.01%). The proportion for cancer cells found on their tissue section slides was 0.41%, which was also 1 ~ 3 times higher than that of Kaohsiung City (0.21%) and other Taiwan areas (0.33%). Among positive Pap smear cases, 74% were from age 45 and above, 37.02% were betel quid chewers, 34.13% were alcoholic, and 15.87% were cigarette smokers. Pap smear cases with all three habits of betel quid chewing, cigarette smoking and alcohol intake were 1.7 times more likely to be positive than those having none of the habits. Those having the habit of cigarette smoking were 1.03 times more likely to be positive than those not having this habit. Those having the habit of alcohol drinking were 4.88 times more likely to be positive than those not having this habit, and the P value reaches an obvious difference. As for the positive cases found in the cervix tissue section slides, those having the habit of cigarette smoking are relatively 2.38 times more likely to be positive than those not having the habit; and those having the habit of alcohol drinking are 1.81 times more likely to be positive than those not having the habit, but the two P values are not significant. As for the dysplasia cases found in the cervix tissue section slides, those having the habit of betel quid chewing are relatively 2.34 times more likely to be positive than those not having the habit; and those having the habit of cigarette smoking are 1.66 times more likely to be positive than those not having the habit, but the two P values are not significant. Thus, in conclusion, regarding the aborigines of Nantou County, alcohol intake has a significant relationship with positive Pap smears. Regarding the strength of association cervical cancer with the three habits of betel quid, cigarette smoking and alcohol intake, alcohol intake shows the strongest correlation, with cigarette smoking next and betel quid chewing the weakest. Key words：betel quid chewing, cigarette smoking,alcohol intake , cervical smears ,