| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所 === 91 === Solid Lipid Nanoparticles (SLNs) are drug carrier system composed of biodegradable substances, which are solid at room temperature. The aim of this study was to improve the dissoluion and stability of Nifedipine by Solid Lipid Nanoparticles (SLNs) technique. In the present study Nifedipine Solid Lipid Nanoparticles were prepared from hot homogenization technique followed by drying with lyophilization process. The matrix chiefly consists of soybean lecithin, stearic acid, glycerol and poloxamer 188® as surfactant.
The physicochemical characteristics of Nifedipine-loaded SLNs were investigated by particle size analysis, scanning electron microscopic analysis, thermal analysis (DSC) and HPLC determination of Nifedipine content. Drug release profiles were studied by dialysis method. The stability test was performed under three different conditions (5℃/ 75 R.H; 15℃/ 75 R.H.; 25℃/ 75 R.H.).
As results, the average diameter of Nifedipine-loaded SLNs is below 120 nm. DSC analysis showed that Nifedipine is dispersed in SLN in an amorphous state. Dissolution studies showed that the dissolution rate was markedly increased in SLNs compared with drug other solid dispersions and pure drug.
Finally, in the stability test under normal light, the Nifedipine-SLNs showing good protective effects of drug from photodegradation.
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