Evidence of Candidate Regions for Familial Gout on Atayal Aborigines by Linkage Analysis and Transmission/Disequilibrium Test.

• Main Authors: ShangLun Chiang, 蔣尚倫
• Other Authors: Ko. YC
• Format: Others
• Language: zh-TW
• Published: 2003
• Online Access: http://ndltd.ncl.edu.tw/handle/85774347110489952309

碩士 === 高雄醫學大學 === 醫學研究所 === 91 === In previous studies，we have found there is a high prevalence of hyperuricemia and gout on Taiwanese aborigines, especially on Bunun, Atayal and Paiwan tribes, and the disease trend towards familial aggregation and codominant inheritance. Familiar Gout is a complex trait disorder, and its candidate-region or candidate-gene are not found yet. To find the major gene of gout, this study collected the gout families of Atayal tribe to mapping the gout disease locus. All of samples came from Atayal tribe, included 23 families and their 154 members. We use 382 STRPs (short tandem repeat polymorphisms) markers on 22 autosomal chromosomes for genotyping and naparametric linkage (NPL) analysis and combined transmission/disequilibrium test (C-TDT) for screening susceptibility loci. By the genome-wide scan, we find regions include 1p32 (D1S2134)、2p25(D2S2952)、4q24(D4S1647, D4S2326) and 14q21(D14S599) have the modest evidence for linkage. Multiple loci in the matched regions display allelic frequently transmission noted at D1S3721 on chromosome 1, D2S2952 on chromosome 2, D4S2623 on chromosome 4, and D14S599 on chromosome 14. Six- and eight-marker haplotypes from the 4q24 region similarly showed transmission in family 9051-1. We suggest the four regions may be worth for further studing candidate genes for familiar gout.