Synthetic Studies on the Key Intermediate of Potent Anti-tumor Natural Products-Saframycin A
碩士 === 朝陽科技大學 === 應用化學系碩士班 === 91 === Saframycin A (1a) is one kind of natural products which show potent antitumor antibiotics. Due to the scant availability from natural sources and difficulty in cultivation, we make an attempt to synthsize derivatives of the Saframycin A (1a) by means of organic...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2003
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| Online Access: | http://ndltd.ncl.edu.tw/handle/zyvy23 |
| Summary: | 碩士 === 朝陽科技大學 === 應用化學系碩士班 === 91 === Saframycin A (1a) is one kind of natural products which show potent antitumor antibiotics. Due to the scant availability from natural sources and difficulty in cultivation, we make an attempt to synthsize derivatives of the Saframycin A (1a) by means of organic synthesis.
The main purpose of this study is to utilize an inexpensive, exhibiting stereo-controlled substance, being a natural amino acid L-tyrosine as a starting material which could be transformed into the key intermediate 34b an optically active dizobicyclo [3.3.1] nonane. 34b may be further transformed to compound 33 which has been synthesized by Dr. E. J.Corey, and subsequently 33 was converted to Saframycin A (1a).
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