| Summary: | 碩士 === 中山醫學大學 === 醫學研究所 === 91 === Abstract
Introduction: Venous thromboembolism is a relatively common clinical problem. Post surgery patients are at the risk of developing thromboembolic complications. Anesthetic procedures and agents possibly changes the blood coagulation profile and subsequently results in postoperative deep venous thromboembolic events. It has been suggested that the incidence of postoperative deep venous thrombosis may be decreased by regional anesthesia. Stress produced by anesthesia and surgery has been associated with release of catecholamines which may trigger blood coagulation cascade. Regional anesthesia has been thought to decrease stress hormone release and thus decrease the incidence of postoperative thromboembolic complications.
The objective of this study was to evaluate the effect of labetalol, an α and β blocker, on blood coagulability in patients who are scheduled to receive general anesthesia.
Material & Methods : Twenty four patients who are presented to have elective gynecologic operations are randomly assigned into two groups. The patients of group A had undergone routine induction and maintenance of general anesthesia, while labetalol was used for group B in addition to routine anesthesia procedures. Venous blood was drawn before induction, at the 1st and 24th hours after the operation. Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen level, antithrombin III and protein C activity were measured. The means of these parameters were compared. The significance of differences was tested with t-test at significance level of 0.05. Ninety-five % confidence intervals of the differences were presented.
Results : There was no significant difference in the means of PT, APTT, fibrinogen level, antithrombin III and protein C activity before induction, at the 1st hour and 24th hours after the operation between the two groups.
Conclusions : Use of labetalol during general anesthesia does not affect PT, APTT, fibrinogen level, antithrombin III and protein C activity at the 1st and 24th hours after surgery in elective gynecological surgery patients. Since the hypercoagulability status in general anesthesia might be due to some other coagulation profile, the risk of thromboembolism might be further studied with completely examining all the risk factors with larger sample size. .
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