The correlation of IL-6 and Mcl-1expression in HPV 16/18 infected lung cancer
碩士 === 中山醫學大學 === 毒理學研究所 === 91 === Lung cancer is the leading cause of cancer death in nonsmoking Taiwanese women since 1982. The aetiology of lung cancer nonsmokers remains unknown. Environmental factors other than cigarette smoking were considered to link with lung cancer incidence of Taiwanese w...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2003
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| Online Access: | http://ndltd.ncl.edu.tw/handle/92788169208858203853 |
| Summary: | 碩士 === 中山醫學大學 === 毒理學研究所 === 91 === Lung cancer is the leading cause of cancer death in nonsmoking Taiwanese women since 1982. The aetiology of lung cancer nonsmokers remains unknown. Environmental factors other than cigarette smoking were considered to link with lung cancer incidence of Taiwanese women. The association between human papillomavirus (HPV) 16/18 infection with nonsmoking Taiwanese female lung cancer has been reported. Previous report indicated that the anti-apoptotic effect of Mcl-1 is mediated by interleukin 6 (IL-6) expression in human cervical cancer tissues and cell lines that is closely associated with HPV infection. In this study, we attempted to reveal whether HPV infection was associated with the induction of Mcl-1 and IL-6 expression in lung tumor tissue in vivo. Immunohistochemistry data showed that 68% and 56% of IL-6 and Mcl-1 in 88 lung tumors had positively immunostainings, respectively. A significant association between IL-6 expression and tumor stage was observed (p = 0.043). The expression of IL-6 and Mcl-1 was significantly associated with HPV 16/18 infection (p = 0.014 and p = 0.004 respectively). We also observed that the expression of IL-6 was significantly correlated with Mcl-1 expression (p < 0.0001). These results strongly suggested that HPV infection may be involved in lung tumorigenesis through IL-6 and anti-apoptosis protein Mcl-1 concomitant expression.
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