| Summary: | 碩士 === 中國醫藥學院 === 環境醫學研究所 === 91 === Salmonella Choleraesuis is a common pathogen in swine population, which also causes serious systematic infection in humans. Antimicrobial treatment was useful in clinical management. However, in recent years, multi-drug-resistance S. Choleraesuis is frequently seen in clinical settings. In order to trace the relationship and find the circulating S. Choleraesuis stains between pigs and humans, chromosomal DNA from 158 pig isolates and 54 human isolates were subjected to molecular analysis by pulsed-field gel electrophoresis (PFGE) with XbaI digestion. In this study, we successfully identified five and nine PFGE genotypes in swine and human isolates, respectively. In the swine isolates, 55% of them were with closely related PFGE patterns, designated as genotype 1 (gt 1). The similar genotype was also identified in 69% of the human isolates. By antimicrobial susceptibility test, 96% and 88% of the swine and human S. Choleraesuis isolates were multi-drug-resistance strains, which were resistant to at least 5 different antibiotics tested. Further stratified by different collection years, S. Choleaesuis with gt1 type was still the most prevalent one in pigs and humans. These observations strongly suggested that multi-drug resistance S. Choleraesuis with unique genotype be circulating between pigs and humans in Taiwan.
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