| Summary: | 碩士 === 國立臺灣大學 === 物理治療學研究所 === 90 === There are few research about the function and quality of life in patients with bone cancer receiving custom-made total knee arthroplasty in the past. The purposes of this research are as follows: 1. To understand the range of motion, muscle strength, proprioception in knee joint of bone tumor patients who underwent wide resection of tumor followed by reconstruction with custom-made total knee replacement. And also their gait, function, and quality of life. 2. To compare the range of motion, muscle strength, proprioception, and gait between patients and age matched control group. 3. To compare the range of motion, muscle strength, and proprioception in knee joint between patient’s affected side and sound side. 4. To compare the difference in range of motion, muscle strength, proprioception, gait, function, and quality of life between patients with different lesion sites (distal femur and proximal tibia). Methods: Twenty bone tumor patients who underwent wide resection of tumor and reconstruction with custom-made total knee replacement, mean age was 21.7±7.3 years old. They were grouped by the lesion sites (distal femur and tibia). There are 20 age matched control subjects in this study. The range of motion was tested with electrogoniometer, muscle strength was tested with Cybex6000, proprioception was evaluated with active and passive angular reposition, gait was evaluated with GaitMatTMII, functions of lower limbs were assessed with functional assessment system developed by Musculoskeletal Tumor Society, and quality of life was assessed with EORTC questionnaire. Results: The range of motion in patient’s affected side was significant smaller than sound side and the control group ( p＜0.05). The muscle strength of patient’s affected side was significant weaker than sound side and control group（p＜0.05）. In proprioception, no significant difference between sound side and affected side was noted, so was between sound side and the control group (p＞0.05). In gait, patient’s speed was slower, step length in sound side was lessened, stance time of affected side was significant shorter than that of sound side, and swing time was significant longer. The mean±SD score of function of patients’ lower limbs was 21.6±2.8, 72.0% of normal subjects. Results of EORTC showed the global health and quality of life was 67.1±19.8. Among the functional scales, cognitive function was the best and physical function was the worst. Among the symptom scales, fatigue was the most important complaint; appetite and sleep were least affected. There was no significant difference in any assessment between the two groups with different lesion sites. Conclusion: The result of this study can be a reference for the function of lower extremities and quality of life of bone tumor patients after custom-made total knee arthroplasty in Taiwan. However the difference between the two groups with different lesion sites need further study.
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