Transduced CDKI p21 induces growth arrest and inhibits apoptosis elicited by oxidative stress
碩士 === 國立海洋大學 === 水產生物技術研究所 === 90 === Abstract Microglials are resident monocyte-lineaged cells in the brain. Their characteristic feature is that they react to injury and diseases of the brain and become functionally activated and generates (ROS) reactive oxygen species. Reac...
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| Format: | Others |
| Language: | zh-TW |
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2002
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| Online Access: | http://ndltd.ncl.edu.tw/handle/01179191779980579820 |
| Summary: | 碩士 === 國立海洋大學 === 水產生物技術研究所 === 90 === Abstract
Microglials are resident monocyte-lineaged cells in the brain. Their characteristic feature is that they react to injury and diseases of the brain and become functionally activated and generates (ROS) reactive oxygen species. Reactive oxygen species play an important role in apoptosis under microglial cells activated.
Progression through the cell cycle is regulated by cyclins and cyclin-dependent kinases (CDK). The cyclin inhibitor p21 can induce G1 arrest and block entry into S phase by inactivating CDKs.
We conciude that transduction of TAT-p21 into cells resulted in the loss of CDK kinase activity, elicited an G1 cell cycle arrest, and inhibited apoptosis elicited by oxidative stress.
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