| Summary: | 碩士 === 國立臺灣師範大學 === 化學研究所 === 90 === Abstract
3,4-methylenedioxyamphetamine (3,4-MDMA) is a strong central nervous system stimulant. Using nonaqueous capillary electrophoresis/fluorescence detection, the precision of the method was evaluated by measuring the repeatability and intermediate precision of migration time and corrected peak height by comparison with a 3,4-MDMA-D5 internal standard. It is possible to determine this drug at a level of 1 ppm without any pre-treatment in less than 5 min. After liquid-liquid extraction, the sample can be condensed and a detection limit of 3,4-MDMA in urine of 50 ppb (S/N = 3) can be achieved.
Lysergic acid diethylamide (LSD) is a powerful psychedelic drug that produces temporary hallucinations and a schizophrenic psychotic state The separation and on-line concentrations of LSD, iso-lysergic acid diethylamide (iso-LSD) and lysergic acid N, N-methylpropylamide (LAMPA) in human urine also were investigated by capillary electrophoresis-fluorescence spectroscopy using a mixture of acetonitrile-methanol-water solution (5:35:60, v/v) containing sodium dodecyl sulfate (100 mM), phosphate (50 mM), and Brij-30 (3 mM). To improve sensitivity, a technique involving sweeping and cation-selective exhaustive injection-sweep-micellar electrokinetic chromato-
graphy (CSEI-sweep-MEKC) were also used for on-line concentration which resulted in detection limits of ~ 20 ppb and ~ 60 ppt, respectively. The separation and on-line identification of LSD in tablets were also investigated by capillary electrophoresis-fluorescence spectroscopy at 77 K and GC/MS.
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