| Summary: | 碩士 === 國立成功大學 === 行為醫學研究所 === 90 === Objective: Chronic fatigue syndrome (CFS) is characterized by medically unexplained debilitating fatigue. Although patients with CFS usually report a wide range of cognitive complaints, neuropsychological studies found only mild dysfunctions. The first aim of present study was in an attempt to obtain neurophysiological evidence for cognitive dysfunction in CFS patients with event-related potentials (ERPs) recording during a prolonged cognitive task that required sustained attention. The second aim was to use ERPs recording to exploit the information processing of CFS patients while they were doing Paced Auditory Serial Addition Task (PASAT), a neuropsychological task of divided attention that commonly found impaired in patients with CFS. Methods: The ERPs were recorded from 10 patients with CFS and 9 healthy controls while they were doing a 30-minute vigilance task and from 6 patients with CFS and 5 health controls while they were doing PASAT (the presentation rates were 4, 3, and 2 seconds). Results: The patients with CFS compared to healthy controls had lower amplitude and area measurement of P300 while they were doing vigilance task. No difference in accuracy or reaction time was found. The amplitude of N130 at FZ was significantly higher in patients with CFS compared to healthy controls while they were doing PASAT, but there was no difference in N130 latency, P230 and N500 amplitude or latency, and no difference on area measurement. Also, no difference on behavior data between groups was found. Conclusion: The P300 amplitude and area measurement of patients with CFS tends to be smaller across electrode sites, implying that the tonic arousal is lower in patients with CFS. The difficulty in patients with CFS on PASAT comes form early process of information processing, not later process. Patients with CFS are able to modify their phasic arousal in response to presentation of vigilance task and PASAT.
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