Research on Molding Parameters of Microprobes for Gene Therapy

• Main Authors: Zhi-Chi Weng, 翁志傑
• Other Authors: Sheng-Jye Hwang
• Format: Others
• Language: zh-TW
• Published: 2002
• Online Access: http://ndltd.ncl.edu.tw/handle/vp437u

碩士 === 國立成功大學 === 機械工程學系碩博士班 === 90 === The component of microprobes combined endoscopies therapy can penetrate cancer cell of stomach or intestines, and then deliver drug or gene into cell for treatment. Bulk micro-machining is the main stream methodology of MEMS technology to produce batch microprobes. Using sing-crystal silicon and anisotropic etchant can make sharp probes or grooves. However, there are two disadvantages. One is the length and shape of microprobe are constrained by etching parameters. The other single-crystal silicon can absorb protein so that it may not be safe for human body. The economic advantage of plastics, we want to develop the injection molding technology will be developed for microprobe component. Due to miniaturization and requirement of high accuracy of micro-featured injection molding, the replicating capacity, dimension precision and processes must be considered. Therefore, the injection molding machine, mold and process condition needs to be improved or even to redesigned. This study is to design and fabricate microprobe for medical treatment. By taking advantages of precision electrical discharge machining and electroforming to fabricate mold insert, then microprobe is manufactured by injection-compression molding after the mold insert put together into the mold. Finally, taguchi method is adapted to find the optimal parameters of injection-compression processes through a series of inspections of microprobe.