| Summary: | 碩士 === 國立中興大學 === 獸醫學系 === 90 === Indenopyridine derivatives are known to be effective antispermatogenic agents. An indenopyridine derivatives, indenopyridine hydrochloride (IH), was examined in this study to understand its extent of antispermatogenic effect. Examinations including testicular histopathology, semen characteristics, and sera testosterone profiles, were conducted. Either male dogs and rats treated with single oral dosage of 30 mg IH/kg BW, resulted in germ cells degeneration, that sloughed into the lumen of the seminiferous tubule. When rats were administrated by 30 mg IH/kg BW for 24 hours, the germ cells showed heterochromatin margination, a character of cell apoptosis observed under the transmissible electron microscopy. From two weeks onwards to eight weeks after IH administration, the dogs exhibited oligospermia or azoospermia. Three months later, the sperm counts per ejaculate recovered. Alkaline phosphatase in seminal plasma elevated significantly (p<0.05) during experimental periods. This suggests that process of spermatogenesis was interrupted. When rats were administrated with double dosage of 30 mg IH/kg in one week apart, the antispermatogenic effect was not different from those treat with single dose. Testosterone profiles were normal in all dog cases examined. Sexual behaviors including, libido, erection capability, and ejaculation were not impaired by IH. IH treatment showed no toxicity to hepatic- renal- functions. Similarly, this compound didn’t affect bone marrow and intestinal epithelium, nor mutagenic potential. Conclusively, IH exclusively inhibits spermatogenesis in a reversible manner. This might result in an episode of male infertility. IH possesses the clinical potential in development of male chemical castration medicine.
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