DNA微陣列基因多重檢定比較之問題

• Main Authors: Ya-hui Lin, 林雅惠
• Other Authors: Hui-min Hsueh
• Format: Others
• Language: zh-TW
• Published: 2003
• Online Access: http://ndltd.ncl.edu.tw/handle/88572570284713155600

碩士 === 國立政治大學 === 統計研究所 === 90 === cDNA microarray technology provides tools to study thousands of genes simultaneously. Since a large number of genes are compared, using a conventional significant test leads to the increase of the type I error rate. To avoid the inflation, the adjustment for multiplicity should be considered and a multiple comparison procedure (MCP) that controls the familywise error rate (FWE) is recommended. However, the conservativeness of a MCP that controls FWE becomes more and more severe as the number of comparisons (genes) increases. Instead of FWE, Benjamini and Hochberg (1995) recommended to control the expected proportion of falsely rejecting hypotheses─the false discovery rate (FDR)─and developed a MCP, which has its FDR under control. In this paper, the error rates CWE, FWE and FDR are fully introduced. A new MCP with FDR controlled is developed and its performance is investigated through intensive simulations. KEY WORDS：Comparison-wise error rate (CWE)；Familywise error rate (FWE)；Multiple comparison procedure (MCP)；False discovery rate (FDR).