Synthesis and Biological Activity of 2-(6-Aryl-3(Z)-hexen-1,5-diynl)benzonitriles derivatives.

碩士 === 國立高雄醫學大學 === 藥學研究所碩士在職專班 === 90 === Six 2-(6-aryl-3(Z)-hexen-1,5-diynyl)benzonitriles were synthesized by the palladium-catalyzed coupling reaction of 1,6-bis(trimethylsilyl)-3(Z)-hexen-1,5-diyne with aryl iodides and 2-iodobenzonitriles, respectively. Screening of the growth inhib...

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Main Authors:	Wen-Hsiung Lu, 盧文雄
Other Authors:	Ming-Jung Wu
Format:	Others
Language:	zh-TW
Published:	2002
Online Access:	http://ndltd.ncl.edu.tw/handle/05999546680898861582

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spelling	ndltd-TW-090KMC015510012016-06-27T16:09:19Z http://ndltd.ncl.edu.tw/handle/05999546680898861582 Synthesis and Biological Activity of 2-(6-Aryl-3(Z)-hexen-1,5-diynl)benzonitriles derivatives. 二-(六-芳香基-三(Z)-己烯-一，五-雙炔)苯腈衍生物之合成與生物活性 Wen-Hsiung Lu 盧文雄碩士國立高雄醫學大學藥學研究所碩士在職專班 90 Six 2-(6-aryl-3(Z)-hexen-1,5-diynyl)benzonitriles were synthesized by the palladium-catalyzed coupling reaction of 1,6-bis(trimethylsilyl)-3(Z)-hexen-1,5-diyne with aryl iodides and 2-iodobenzonitriles, respectively. Screening of the growth inhibition activity of these compounds against the KB and Hela cells, all compounds reveal potent cytotoxicity against KB and Hela cells with the IC50 value are less than 10μg/ml, except compound 23a which is inactive against KB cell. Ming-Jung Wu 吳明忠 2002 學位論文 ; thesis 0 zh-TW
collection	NDLTD
language	zh-TW
format	Others
sources	NDLTD
description	碩士 === 國立高雄醫學大學 === 藥學研究所碩士在職專班 === 90 === Six 2-(6-aryl-3(Z)-hexen-1,5-diynyl)benzonitriles were synthesized by the palladium-catalyzed coupling reaction of 1,6-bis(trimethylsilyl)-3(Z)-hexen-1,5-diyne with aryl iodides and 2-iodobenzonitriles, respectively. Screening of the growth inhibition activity of these compounds against the KB and Hela cells, all compounds reveal potent cytotoxicity against KB and Hela cells with the IC50 value are less than 10μg/ml, except compound 23a which is inactive against KB cell.
author2	Ming-Jung Wu
author_facet	Ming-Jung Wu Wen-Hsiung Lu 盧文雄
author	Wen-Hsiung Lu 盧文雄
spellingShingle	Wen-Hsiung Lu 盧文雄 Synthesis and Biological Activity of 2-(6-Aryl-3(Z)-hexen-1,5-diynl)benzonitriles derivatives.
author_sort	Wen-Hsiung Lu
title	Synthesis and Biological Activity of 2-(6-Aryl-3(Z)-hexen-1,5-diynl)benzonitriles derivatives.
title_short	Synthesis and Biological Activity of 2-(6-Aryl-3(Z)-hexen-1,5-diynl)benzonitriles derivatives.
title_full	Synthesis and Biological Activity of 2-(6-Aryl-3(Z)-hexen-1,5-diynl)benzonitriles derivatives.
title_fullStr	Synthesis and Biological Activity of 2-(6-Aryl-3(Z)-hexen-1,5-diynl)benzonitriles derivatives.
title_full_unstemmed	Synthesis and Biological Activity of 2-(6-Aryl-3(Z)-hexen-1,5-diynl)benzonitriles derivatives.
title_sort	synthesis and biological activity of 2-(6-aryl-3(z)-hexen-1,5-diynl)benzonitriles derivatives.
publishDate	2002
url	http://ndltd.ncl.edu.tw/handle/05999546680898861582
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Synthesis and Biological Activity of 2-(6-Aryl-3(Z)-hexen-1,5-diynl)benzonitriles derivatives.

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