Synthesis and Biological Activity of 2-(6-Aryl-3(Z)-hexen-1,5-diynl)benzonitriles derivatives.
碩士 === 國立高雄醫學大學 === 藥學研究所碩士在職專班 === 90 === Six 2-(6-aryl-3(Z)-hexen-1,5-diynyl)benzonitriles were synthesized by the palladium-catalyzed coupling reaction of 1,6-bis(trimethylsilyl)-3(Z)-hexen-1,5-diyne with aryl iodides and 2-iodobenzonitriles, respectively. Screening of the growth inhib...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2002
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| Online Access: | http://ndltd.ncl.edu.tw/handle/05999546680898861582 |
| Summary: | 碩士 === 國立高雄醫學大學 === 藥學研究所碩士在職專班 === 90 === Six 2-(6-aryl-3(Z)-hexen-1,5-diynyl)benzonitriles were synthesized by the palladium-catalyzed coupling reaction of 1,6-bis(trimethylsilyl)-3(Z)-hexen-1,5-diyne with aryl iodides and 2-iodobenzonitriles, respectively. Screening of the growth inhibition activity of these compounds against the KB and Hela cells, all compounds reveal potent cytotoxicity against KB and Hela cells with the IC50 value are less than 10μg/ml, except compound 23a which is inactive against KB cell.
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