| Summary: | 碩士 === 高雄醫學大學 === 醫學研究所 === 90 === Absract
Background－ There is controversy regarding the association of the angiotensin-converting enzyme deletion-insertion (ACE I /D) polymorphism with hypertension. The angiotensinogen gene (AGT), which encodes the precursor of the vasoactive hormone angiotensin II, has been reported to be associated with hypertension in Caucasian and Japanese populations. We examined the relationship between hypertension and in two common molecular variants of AGT, T174M and M235T and the ACE I /D polymorphism in the southern Aborigines of Taiwan. We investigated these relations in a population-based sample by using association analyses.
METHODS and Result － Blood pressure was measured according to standard protocols, and information on age, sex, body mass index, plasma triglyceride, cholesterol and uric acid was collected by trained interviewers using standardized questionnaires. The ACE I/D polymorphism and two common molecular variants of AGT, T174M and M235T polymorphism were identified by using a polymerase chain reaction assay. The association of AGT genotypes, ACE I /D genotypes and blood pressure was examined in chi-squares test（X2 test）. The respective control I and D allele frequencies for ACE I /D gene were 52﹪and 48﹪, T and M allele frequencies for T174M were 87﹪ and 13﹪, and 98﹪ and 2﹪ for M235T in the southern Aborigines of Taiwan. In logistic regression analysis, the odds ratios for hypertension among Aborigines for the DD ＋ DI genotypes and TG≧250 mg/ dL vs. II＋TG<250 mg/dL were 4.1（1.4－1.9）. For genotypes of T174M, MM＋TM and TG≧250 mg/ dL vs. TT＋TG<250 mg/dL were 4.1（0.8-22.3）。
CONCLUSIONS－ In summary, our analyses suggest that the molecular variants of AGT and angiotensin-converting enzyme deletion-insertion (ACE I /D) polymorphism may not be associated with variations of blood pressure in the southern Aborigines of Taiwan. The logistic regression analysis to assess gene-environment interaction of hypertension to reveal association with ACE DD＋ID and TG>=250 mg/ dL.
KEY WORDS－ Hypertension, Angiotensinogen, Angiotensin-converting enzyme .
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