Study of risk factor of congenital heart disease in children
碩士 === 高雄醫學大學 === 公共衛生學研究所 === 90 === A matched-paired case-control study was designed for the exploration of risk factores in congenital heart disease of babies. 420 babies who were given births during 1998 — 2001 period were included in this study. 210 newborn babies who were diagnosed with physic...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2002
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| Online Access: | http://ndltd.ncl.edu.tw/handle/97935920905111469575 |
| Summary: | 碩士 === 高雄醫學大學 === 公共衛生學研究所 === 90 === A matched-paired case-control study was designed for the exploration of risk factores in congenital heart disease of babies. 420 babies who were given births during 1998 — 2001 period were included in this study. 210 newborn babies who were diagnosed with physical examination and echocardiography as congenital heart disease patients by cardiologists in Kaohsiung Veterans Hospital. Another 210 selected matched-paired non-heart diseased babies whose ages and genders were paired with the study group from the pediatric of the hospital were used as control group. A specially designed structured questionnaire was applied to all babies’ caretakers by trained personnel.
The purposes of this study were to probe the risk factors of congenital heart disease. The probable risk factors of congenital heart disease were analyzed with multiple variable conditional logistic regression.
The results showed that the following factors were significantly different between case group and control group: grandfather of mother’s side ( p = 0.039) or other relatives ( p = 0.02) had heart disease history; flu infection during pregnancy ( p = 0.036); pickled vegetable intake ( p = 0.035); contraception with safety period method ( p = 0.041) and pleasant pregnancy ( p = 0.04). After controlling probable confounding factors, only pickled vegetable intake showed 2.24 times riskier ( OR = 2.24；95% CI = 1.005 - 4.990) in multiple variable conditional logistic regression. Considering collinear interference, the relative risk for pleasant pregnancy is 0.64 times (OR = 0.64; 95% CI = 0.416 — 0.990) in comparison with unpleasant pregnancy when pickled vegetable intake variable is removed. Those with congenital heart disease family history are 1.98 times riskier than those without (OR = 1.98; 95% CI = 1.043 — 3.769). The difference is significant.
Congenital heart disease is one of congenital defects, but there are few domestic studies on its risk factors. This study could be a pioneer study on relevant fields.
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