| Summary: | 碩士 === 中國醫藥學院 === 中西醫結合研究所 === 90 === The purpose of this study is to evaluate whether added Bao-Yuan Tang (aBYT) can improve the renal anemia of uremic patients receiving long-term hemodialysis (HD) and whether the Chinese syndromes would make a clinical effect for aBYT.
We included 69 patients who have had taking erythropoietin (EPO) and whose hematocrit (Hct) were >=20% and <30% without the condition of infection, inflammation, bleeding, malignancy and iron deficiency.
The included patients were non-randomly divided into 2 groups. One treated group (32 cases) took daily 20gm condensed powder (containing pro-drug 36gm) of aBYT by 3 divided doses after meal under the previous EPO administration for 3 months. The other control group (37 cases) just received previous medication with the administration of EPO. We compared hemoglobin, Hct, serum ferritin, transferrin saturation (TS), and total symptomatic scores, and/or creatine phospho-kinase (CPK) of patients between these 2 groups after the treatment of one and three months. We also differentiated all patients into five different Chinese syndromes including Chi-vacuity, Yin-vacuity, Yang-vacuity, both Chi and Yin Vacuity, and both Yin and Yang Vacuity. We would look for the clinical effect of the Chinese syndromes for aBYT.
The all data were not indifferent between these 2 groups before study and after 1 and 3 months except initial HD duration. At the comparison of different Chinese syndromes, CPK of the treated Chi-vacuity patients lowered more significantly than that of the control Chi-vacuity ones (-739±1124 IU/L vs 0±31 IU/L) after 3 months of treatment. Transferrin saturation of the treated both Chi and Yin Vacuity patients lowered significantly than that of control ones (-4.9±10.8% vs 4.3±4%) after one month of treatment (P=0.048). The mean TS of the treated both Chi and Yin Vacuity patients was less than that of control group (27.6±6.1% vs 39.1±17.3) (P=0.055), but did not lower more significantly after 3 months of treatment. The lowering of TS of treated patients with last syndrome was significantly related to the elevation of Hct of them at linear regression (r=-0.138) after 3 months of treatment.
The renal anemia of uremic patients with long-term HD could not change significantly under the addictive treatment of 3 months of aBYT. But the change of hematocrit of treated patients with both Chi and Yin Vacuity was negatively related to that of TS of them with statistical significance by linear regression after 3 months of aBYT treatment.
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